Miércoles, 25 de marzo de 2026:
At night, in my Japanese-style room, I watched the following movie.
Recorded on a USB-HDD (registration number 3) connected to a DIGA (2017 model). Aired on TV Tokyo on September 8, 2022, at 1:40 PM.
Afternoon Movie Showcase: "DESPERATE MEASURES" (1998, USA. Japanese dubbed).
It was interesting.
I had seen this movie on television quite some time ago, but I had completely forgotten the plot, the faces of the cast, and even the title of the movie.
I was surprised to learn that the FBI has detailed blood information on all past and present inmates across the United States. HLA is information that cannot be obtained from a regular blood test taken during a health checkup in prison (what we usually call "blood type," such as A or AB, is the type of red blood cells). I don't know if that's really true, though.
In Japan, the Japan Bone Marrow Bank was established in December 1991 to mediate bone marrow donation for patients who, like the protagonist's son in this film, do not have blood relatives who can donate.
Even in present-day Japan, it is said that only about half of the patients waiting for a donor are able to receive a bone marrow transplant (BMT).
In recent years, transplants from parents with only one matching HLA set have been performed using immunosuppressive therapy. Cord blood transplants are also being performed.
However, if a bone marrow transplant is received from a donor with a partial HLA mismatch, there is a higher risk of complications such as a lack of white blood cell count after a certain period following the transplant, or a decrease in white blood cell count after an increase, as well as GVHD.
Even if the transplant is successful, there is a risk of rejection and Graft-Versus-Host Disease (GVHD), requiring treatment with immunosuppressants. Because it takes time for the immune system to recover, the risk of infection increases during that time.
On the other hand, bone marrow donors may experience complications from general anesthesia and puncture. Peripheral blood stem cell donors are at risk of complications associated with G-CSF injections and extracorporeal circulation of blood.
It seems that fundamentally solving the problem of donor shortage will be difficult. We may have no choice but to wait until regenerative medicine advances to the point where organs can be manufactured using one's own cells.
However, that seems to be more than half a century away.
cf:
https://www.kango-roo.com/word/10424
https://ganjoho.jp/public/dia_tre/treatment/HSCT/hsct01.html
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